Alexander Lin, MD, MBA, MSc

CA3D+ Co-Director
Plastic Surgery

Dr. Alexander Y. Lin is a Plastic surgeon who specializes in craniofacial and maxillofacial surgery (operations on the skull, face, and jaw), as well as Plastic surgery for pediatric conditions. He is Director of Surgical Innovations for UCSF Plastic Surgery. He is also co-director of the UCSF Craniofacial Center and co-director of the UCSF Center for Advanced 3D+ Technologies, serving as the Oakland site director for both.

Lin's mission in medicine – guiding his practice, research and innovations – is to improve the lives of children and their families. In patient care, he focuses on what makes us human: our faces, speech (palate), and hands. Specifically, he provides care for patients with cleft lip-nose-palate or other conditions of facial structures such as ear reconstruction. He also performs surgery to correct problems with the bones of the skull and face (due to disorders such as craniosynostosis), the jaw (which can cause poor teeth alignment and breathing problems), and the orbit (eye socket).

In his translational research, Lin focuses on 3D printing and advanced visualization technologies to allow the use of sterile models and improve surgery by facilitating smaller incisions – serving to make procedures faster and more accurate. He has funded grants to develop artificial intelligence applications for detecting speech problems earlier in children's development, which can enable kids to receive speech therapy or corrective surgery sooner. He also studies how to merge scaffolding (implantable materials that support tissue growth) with biologic tissues for complex reconstruction surgeries.

After earning his bachelor's and master's degrees at Stanford University, Lin earned his medical degree at the Johns Hopkins University School of Medicine. He completed a residency in general surgery and plastic and reconstructive surgery at UCSF, which included a two-year research fellowship in vascular immunobiology at Massachusetts General Hospital. He completed a fellowship in craniofacial, maxillofacial and pediatric plastic surgery at Children's Hospital of Pittsburgh. He also earned a master of business administration degree, with a focus on innovation, from Washington University in St. Louis.

Prior to joining UCSF, Lin served as Chief of Plastic surgery at Saint Louis University (SLU) School of Medicine. There, he held the Alan A. and Edith L. Wolff Endowed Chair in Craniofacial, Maxillofacial and Pediatric Plastic Surgery, and co-founded and co-directed the 3D Printing Center of Excellence at SSM Health Cardinal Glennon Children's Hospital, where he also directed the St. Louis Cleft-Craniofacial Center.

Nationally, Lin provides leadership in three key roles, serving on the American Society of Maxillofacial Surgeons' executive board as vice president of administrative duties, as chair of the craniomaxillofacial section of the American Society of Plastic Surgeons' exam committee, and as past chair of the clinical study section of the Plastic Surgery Foundation (which supports impactful research through its grants program).

Publications: 

ChatGPT for improving postoperative instructions in multiple fields of plastic surgery.

Journal of plastic, reconstructive & aesthetic surgery : JPRAS

Zhang A, Li CXR, Piper M, Rose J, Chen K, Lin AY

Surgical Management in Isolated Squamosal Craniosynostosis: A Systematic Review.

Annals of plastic surgery

Fallahian F, Meyer A, Tadisina KK, Lin AY

The Role of Postoperative Nasal Stents in Cleft Rhinoplasty: A Systematic Review.

The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association

Nguyen DC, Myint JA, Lin AY

Seeing Cleft Lip from a New Angle: Crowdsourcing to Determine Whether Scar Severity or Lip Angle Matters More to the General Public.

Plastic and reconstructive surgery

Sescleifer AM, Francoisse CA, Osborn TA, Rector JD, Lin AY

Defining Ideal External Female Genital Anatomy via Crowdsourcing Analysis.

Aesthetic surgery journal

Frojo G, Kareh AM, Probst KX, Rector JD, Plikaitis CM, Lund HG, Lin AY

Three-dimensional printing in medicine: a systematic review of pediatric applications.

Pediatric research

Francoisse CA, Sescleifer AM, King WT, Lin AY

Preparing for the Plastic Surgery In-Service Exam: Evidence-Based Essentials for the Plastic Surgery Resident.

Plastic and reconstructive surgery

Frojo G, Tadisina KK, Kaswan S, Doston A, Lin AY

Tissue Engineering Scaffolds Fabricated in Dissolvable 3D-Printed Molds for Patient-Specific Craniofacial Bone Regeneration.

Journal of functional biomaterials

de la Lastra AA, Hixon KR, Aryan L, Banks AN, Lin AY, Hall AF, Sell SA

Systematic Review: Online Crowdsourcing to Assess Perceptual Speech Outcomes.

The Journal of surgical research

Sescleifer AM, Francoisse CA, Lin AY

Demystifying the "Triple Point: " Technical Nuances of the Fronto-Orbital Advancement.

The Journal of craniofacial surgery

Lopez CD, Kumar A, Lin AY, Bonfield CM, Weinzweig J, Naidich T, Smith CM, Taub PJ

Temporomandibular Joint Septic Arthritis.

Plastic and reconstructive surgery. Global open

Frojo G, Tadisina KK, Shetty V, Lin AY

The Plastic Surgery Match: A Quantitative Analysis of Applicant Impressions From the Interview Visit.

Annals of plastic surgery

Frojo G, Tadisina KK, Pressman Z, Chibnall JT, Lin AY, Kraemer BA

Congress of Neurological Surgeons Systematic Review and Evidence-Based Guideline for the Diagnosis of Patients With Positional Plagiocephaly: The Role of Imaging.

Neurosurgery

Mazzola C, Baird LC, Bauer DF, Beier A, Durham S, Klimo P, Lin AY, McClung-Smith C, Mitchell L, Nikas D, Tamber MS, Tyagi R, Flannery AM

Congress of Neurological Surgeons Systematic Review and Evidence-Based Guideline for the Management of Patients With Positional Plagiocephaly: The Role of Physical Therapy.

Neurosurgery

Baird LC, Klimo P, Flannery AM, Bauer DF, Beier A, Durham S, Lin AY, McClung-Smith C, Mitchell L, Nikas D, Tamber MS, Tyagi R, Mazzola C

Congress of Neurological Surgeons Systematic Review and Evidence-Based Guideline on the Management of Patients With Positional Plagiocephaly: The Role of Repositioning.

Neurosurgery

Klimo P, Lingo PR, Baird LC, Bauer DF, Beier A, Durham S, Lin AY, McClung-Smith C, Mitchell L, Nikas D, Tamber MS, Tyagi R, Mazzola C, Flannery AM

Congress of Neurological Surgeons Systematic Review and Evidence-Based Guideline on the Role of Cranial Molding Orthosis (Helmet) Therapy for Patients With Positional Plagiocephaly.

Neurosurgery

Tamber MS, Nikas D, Beier A, Baird LC, Bauer DF, Durham S, Klimo P, Lin AY, Mazzola C, McClung-Smith C, Mitchell L, Tyagi R, Flannery AM

Congress of Neurological Surgeons Systematic Review and Evidence-Based Guidelines for the Management of Patients With Positional Plagiocephaly: Executive Summary.

Neurosurgery

Flannery AM, Tamber MS, Mazzola C, Klimo P, Baird LC, Tyagi R, Bauer DF, Beier A, Durham S, Lin AY, McClung-Smith C, Mitchell L, Nikas D

Guidelines: Congress of Neurological Surgeons Systematic Review and Evidence-Based Guideline for the Diagnosis of Patients With Positional Plagiocephaly: The Role of Imaging.

Neurosurgery

Mazzola C, Baird LC, Bauer DF, Beier A, Durham S, Klimo P, Lin AY, McClung-Smith C, Mitchell L, Nikas D, Tamber MS, Tyagi R, Flannery AM

Guidelines: Congress of Neurological Surgeons Systematic Review and Evidence-Based Guideline for the Management of Patients With Positional Plagiocephaly: The Role of Physical Therapy.

Neurosurgery

Baird LC, Klimo P, Flannery AM, Bauer DF, Beier A, Durham S, Lin AY, McClung-Smith C, Mitchell L, Nikas D, Tamber MS, Tyagi R, Mazzola C

Guidelines: Congress of Neurological Surgeons Systematic Review and Evidence-Based Guideline on the Management of Patients With Positional Plagiocephaly: The Role of Repositioning.

Neurosurgery

Klimo P, Lingo PR, Baird LC, Bauer DF, Beier A, Durham S, Lin AY, McClung-Smith C, Mitchell L, Nikas D, Tamber MS, Tyagi R, Mazzola C, Flannery AM

Guidelines: Congress of Neurological Surgeons Systematic Review and Evidence-Based Guideline on the Role of Cranial Molding Orthosis (Helmet) Therapy for Patients With Positional Plagiocephaly.

Neurosurgery

Tamber MS, Nikas D, Beier A, Baird LC, Bauer DF, Durham S, Klimo P, Lin AY, Mazzola C, McClung-Smith C, Mitchell L, Tyagi R, Flannery AM

Development of Volunteer International Craniofacial Surgery Missions: The Komedyplast Protocol.

The Journal of craniofacial surgery

Taub PJ, Lin AY, Cladis FP, Baker SB, Gooden CK, Kumar A, Losee JE, Menard R, Starks R, Duncan JA, De Pawlikowski W, Cecchi AW, Weinzweig J

Custom porous polyethylene implants for large-scale pediatric skull reconstruction: early outcomes.

The Journal of craniofacial surgery

Lin AY, Kinsella CR, Rottgers SA, Smith DM, Grunwaldt LJ, Cooper GM, Losee JE

Rhinoplasty sizers.

Aesthetic plastic surgery

McMahon D, Lin A, Reddy V, Gruber RP

Aortic aneurysm generation in mice with targeted deletion of integrin-linked kinase in vascular smooth muscle cells.

Circulation research

Shen D, Li J, Lepore JJ, Anderson TJ, Sinha S, Lin AY, Cheng L, Cohen ED, Roberts JD, Dedhar S, Parmacek MS, Gerszten RE

BMP-2-mediated regeneration of large-scale cranial defects in the canine: an examination of different carriers.

Plastic and reconstructive surgery

Kinsella CR, Bykowski MR, Lin AY, Cray JJ, Durham EL, Smith DM, DeCesare GE, Mooney MP, Cooper GM, Losee JE

Acellular dermal matrix in the treatment and prevention of exposed vertical expandable prosthetic titanium ribs.

Spine

Gill R, Kinsella CR, Lin AY, Grunwaldt LJ, Jiang S, Deeney VF, Losee J

Nasal strips for evaluating and classifying valvular nasal obstruction.

Aesthetic plastic surgery

Gruber RP, Lin AY, Richards T

A predictive test and classification for valvular nasal obstruction using nasal strips.

Plastic and reconstructive surgery

Gruber RP, Lin AY, Richards T

Pharmacological inhibition of BLT1 diminishes early abdominal aneurysm formation.

Atherosclerosis

Kristo F, Hardy GJ, Anderson TJ, Sinha S, Ahluwalia N, Lin AY, Passeri J, Scherrer-Crosbie M, Gerszten RE

Interferon-gamma and the interferon-inducible chemokine CXCL10 protect against aneurysm formation and rupture.

Circulation

King VL, Lin AY, Kristo F, Anderson TJ, Ahluwalia N, Hardy GJ, Owens AP, Howatt DA, Shen D, Tager AM, Luster AD, Daugherty A, Gerszten RE

Inhibited aortic aneurysm formation in BLT1-deficient mice.

Journal of immunology (Baltimore, Md. : 1950)

Ahluwalia N, Lin AY, Tager AM, Pruitt IE, Anderson TJ, Kristo F, Shen D, Cruz AR, Aikawa M, Luster AD, Gerszten RE

Chemokine CXCL10 promotes atherogenesis by modulating the local balance of effector and regulatory T cells.

Circulation

Heller EA, Liu E, Tager AM, Yuan Q, Lin AY, Ahluwalia N, Jones K, Koehn SL, Lok VM, Aikawa E, Moore KJ, Luster AD, Gerszten RE